LymphedemaV1, Main, Exploration, bibRecord, 002844

Mechanical Forces and Lymphatic Transport

Identifieur interne : 002844 ( Main/Exploration ); précédent : 002843; suivant : 002845

Mechanical Forces and Lymphatic Transport

Auteurs : Jerome W. Breslin

Source :

Microvascular research [ 0026-2862 ] ; 2014.

RBID : PMC:4267889

Descripteurs français

KwdFr :
- Animaux, Cellules endothéliales, Contrainte mécanique, Humains, Liquide extracellulaire, Lymphoedème, Noeuds lymphatiques, Perméabilité, Pression, Résistance au cisaillement, Souris, Système lymphatique (physiologie), Transport biologique, Vaisseaux lymphatiques (physiologie).
MESH :
- physiologie : Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Cellules endothéliales, Contrainte mécanique, Humains, Liquide extracellulaire, Lymphoedème, Noeuds lymphatiques, Perméabilité, Pression, Résistance au cisaillement, Souris, Transport biologique.

English descriptors

KwdEn :
- Animals, Biological Transport, Endothelial Cells, Extracellular Fluid, Humans, Lymph Nodes, Lymphatic System (physiology), Lymphatic Vessels (physiology), Lymphedema, Mice, Permeability, Pressure, Shear Strength, Stress, Mechanical.
MESH :
- physiology : Lymphatic System, Lymphatic Vessels.
- Animals, Biological Transport, Endothelial Cells, Extracellular Fluid, Humans, Lymph Nodes, Lymphedema, Mice, Permeability, Pressure, Shear Strength, Stress, Mechanical.

Abstract

This review examines current understanding of how the lymphatic vessel network can optimize lymph flow in response to various mechanical forces. Lymphatics are organized as a vascular tree, with blind-ended initial lymphatics, precollectors, prenodal collecting lymphatics, lymph nodes, postnodal collecting lymphatics and the larger trunks (thoracic duct and right lymph duct) that connect to the subclavian veins. The formation of lymph from interstitial fluid depends heavily on oscillating pressure gradients to drive fluid into initial lymphatics. Collecting lymphatics are segmented vessels with unidirectional valves, with each segment, called a lymphangion, possessing an intrinsic pumping mechanism. The lymphangions propel lymph forward against a hydrostatic pressure gradient. Fluid is returned to the central circulation both at lymph nodes and via the larger lymphatic trunks. Several recent developments are discussed, including: evidence for the active role of endothelial cells in lymph formation; recent developments on how inflow pressure, outflow pressure, and shear stress affect pump function of the lymphangion; lymphatic valve gating mechanisms; collecting lymphatic permeability; and current interpretations of the molecular mechanisms within lymphatic endothelial cells and smooth muscle. Improved understanding of the physiological mechanisms by lymphatic vessels sense mechanical stimuli, integrate the information, and generate the appropriate response is key for determining the pathogenesis of lymphatic insufficiency and developing treatments for lymphedema.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267889

DOI: 10.1016/j.mvr.2014.07.013
PubMed: 25107458
PubMed Central: 4267889

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
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<term>Endothelial Cells</term>
<term>Extracellular Fluid</term>
<term>Humans</term>
<term>Lymph Nodes</term>
<term>Lymphatic System (physiology)</term>
<term>Lymphatic Vessels (physiology)</term>
<term>Lymphedema</term>
<term>Mice</term>
<term>Permeability</term>
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<term>Cellules endothéliales</term>
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<term>Liquide extracellulaire</term>
<term>Lymphoedème</term>
<term>Noeuds lymphatiques</term>
<term>Perméabilité</term>
<term>Pression</term>
<term>Résistance au cisaillement</term>
<term>Souris</term>
<term>Système lymphatique (physiologie)</term>
<term>Transport biologique</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
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<term>Vaisseaux lymphatiques</term>
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<term>Lymphatic Vessels</term>
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<term>Biological Transport</term>
<term>Endothelial Cells</term>
<term>Extracellular Fluid</term>
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<term>Lymph Nodes</term>
<term>Lymphedema</term>
<term>Mice</term>
<term>Permeability</term>
<term>Pressure</term>
<term>Shear Strength</term>
<term>Stress, Mechanical</term>
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<term>Cellules endothéliales</term>
<term>Contrainte mécanique</term>
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<term>Liquide extracellulaire</term>
<term>Lymphoedème</term>
<term>Noeuds lymphatiques</term>
<term>Perméabilité</term>
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<front><div type="abstract" xml:lang="en"><p id="P2">This review examines current understanding of how the lymphatic vessel network can optimize lymph flow in response to various mechanical forces. Lymphatics are organized as a vascular tree, with blind-ended initial lymphatics, precollectors, prenodal collecting lymphatics, lymph nodes, postnodal collecting lymphatics and the larger trunks (thoracic duct and right lymph duct) that connect to the subclavian veins. The formation of lymph from interstitial fluid depends heavily on oscillating pressure gradients to drive fluid into initial lymphatics. Collecting lymphatics are segmented vessels with unidirectional valves, with each segment, called a lymphangion, possessing an intrinsic pumping mechanism. The lymphangions propel lymph forward against a hydrostatic pressure gradient. Fluid is returned to the central circulation both at lymph nodes and via the larger lymphatic trunks. Several recent developments are discussed, including: evidence for the active role of endothelial cells in lymph formation; recent developments on how inflow pressure, outflow pressure, and shear stress affect pump function of the lymphangion; lymphatic valve gating mechanisms; collecting lymphatic permeability; and current interpretations of the molecular mechanisms within lymphatic endothelial cells and smooth muscle. Improved understanding of the physiological mechanisms by lymphatic vessels sense mechanical stimuli, integrate the information, and generate the appropriate response is key for determining the pathogenesis of lymphatic insufficiency and developing treatments for lymphedema.</p>
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Serveur d'exploration sur le lymphœdème

Mechanical Forces and Lymphatic Transport

Mechanical Forces and Lymphatic Transport

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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